James R. Gossage, MD
To the Editors: Laupacis and colleagues (1) are to be commended on their excellent analysis of the influence of completed studies on ongoing clinical trials. Their decision to stop the trial and perform the final analysis was ethical and courageous. "Aborting" a mission to which considerable time, money, and patient participation have been devoted is frustrating in many ways.
Two points are worthy of further comment. They refer to the desirability of a "meta-analysis when different groups are evaluating a similar problem." However, different groups should not be evaluating a similar problem. Better mechanisms are needed to organize large multicentered
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Gossage JR. Clinical Trials: To Terminate or Not To Terminate. Ann Intern Med. 1992;116:699–700. doi: 10.7326/0003-4819-116-8-699
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Published: Ann Intern Med. 1992;116(8):699-700.
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Print ISSN: 0003-4819 | Online ISSN: 1539-3704
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