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In this era of monoclonal antibodies, the polymerase chain reaction, and fourth-generation cephalosporins, the crude techniques used to discover and produce the first antibiotics are difficult to appreciate. But how exciting this discovery was to those of us entering clinical medicine at the time. The potential for reducing the mortality and morbidity from infectious diseases was exhilarating.
This small volume is a collection of papers presented by a contemporary of Rene Dubos on the 50th anniversary of Du-bos' discovery of gramicidin, an antibiotic still used in topical preparations. Medical historians and research scientists will enjoy the details of isolation, purification,
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Launching the Antibiotic Era: Personal Accounts of the Discovery and Use of the First Antibiotics. Ann Intern Med. 1992;116:1039. doi: 10.7326/0003-4819-116-12-1039_2
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Published: Ann Intern Med. 1992;116(12_Part_1):1039.
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Print ISSN: 0003-4819 | Online ISSN: 1539-3704
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