James E. Tcheng, MD; John D. Jackman Jr., MD; Charlotte L. Nelson, MS; Laura H. Gardner, BS; L. Richard Smith, PhD; J. Scott Rankin, MD; Robert M. Califf, MD; Richard S. Stack, MD
▪ Objective: To describe outcomes of patients sustaining an acute myocardial infarction complicated by mitral regurgitation managed with contemporary reperfusion therapies.
▪ Design: Inception cohort case study. Long-term follow-up was obtained in 99% of all patients.
▪ Setting: University referral center.
▪ Patients: A series of 1480 consecutive patients presenting between April 1986 and March 1989 who had emergency cardiac catheterization within 6 hours of infarction. Fifty patients were found to have moderately severe or severe mitral regurgitation.
▪ Outcome Measures: Mortality; follow-up cardiac catheterization in patients with regurgitation.
▪ Results: Acute ischemic moderately severe to severe (3 + or 4 +) mitral regurgitation was associated with a mortality of 24% at 30 days (95% Cl, 12% to 36%), 42% at 6 months (Cl, 28% to 56%), and 52% at 1 year (Cl, 38% to 66%); multivariable analysis identified 3 + or 4 + mitral regurgitation as a possible independent predictor of mortality (P = 0.06). Patients with mitral regurgitation tended to be female, older, and to have cerebrovascular disease, diabetes, and preexisting symptomatic coronary artery disease. A physical examination did not identify 50% of patients with moderately severe to severe regurgitation. Acute reperfusion with thrombolysis or angioplasty did not reliably reverse valvular incompetence. In this observational study, the greatest in-hospital and 1-year mortalities were seen in patients reperfused with emergency balloon angioplasty, whereas patients managed medically or with coronary bypass surgery had lower mortalities.
▪ Conclusions: Moderately severe to severe (3 + or 4 +) mitral regurgitation complicating acute myocardial infarction portends a grave prognosis. Acute reperfusion does not reduce mortality to levels experienced by patients with lesser degrees of mitral regurgitation nor does it reliably restore valvular competence.
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Tcheng JE, Jackman JD, Nelson CL, Gardner LH, Smith LR, Rankin JS, et al. Outcome of Patients Sustaining Acute Ischemic Mitral Regurgitation during Myocardial Infarction. Ann Intern Med. 1992;117:18–24. doi: 10.7326/0003-4819-117-1-18
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Published: Ann Intern Med. 1992;117(1):18-24.
Acute Coronary Syndromes, Cardiology, Coronary Heart Disease, Emergency Medicine, Valvular Heart Disease.
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Print ISSN: 0003-4819 | Online ISSN: 1539-3704
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