Charis Eng, MD, PhD; Francis A. Farraye, MD; Lawrence N. Shulman, MD; Mark A. Peppercorn, MD; Celeste M. Krauss, MD; Jean M. Connors, MD; Richard M. Stone, MD
Eng C, Farraye FA, Shulman LN, Peppercorn MA, Krauss CM, Connors JM, et al. The Association between the Myelodysplastic Syndromes and Crohn Disease. Ann Intern Med. 1992;117:661-662. doi: 10.7326/0003-4819-117-8-661
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Published: Ann Intern Med. 1992;117(8):661-662.
The myelodysplastic syndromes are a heterogeneous group of bone marrow stem-cell disorders characterized by peripheral cytopenias and hypercellular dysplastic bone marrows (1, 2). The myelodysplastic syndromes, as defined in the French-American-British classification (2), include refractory anemia, refractory anemia with ringed sideroblasts, refractory anemia with excess blasts, refractory anemia with excess blasts in transformation, and chronic myelomonocytic leukemia. Crohn disease, an inflammatory bowel disease, is characterized by specific pathologic and endoscopic gastrointestinal mucosal findings; these include chronic inflammation, noncaseating granulomas, skip lesions, and aphthous ulcerations (3). Unlike the frequent occurrence of clonal chromosomal abnormalities in the bone marrow cells of patients
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Gastroenterology/Hepatology, Inflammatory Bowel Disease.
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