Bruce F. Scharschmidt, MD; Michael J. Held, MA; Harry H. Hollander, MD; Alexandra E. Read, MD; Joel E. Lavine, MD, PhD; Genevieve Veereman, MD; Richard F. McGuire, MD; M. Michael Thaler, MD
Scharschmidt BF, Held MJ, Hollander HH, Read AE, Lavine JE, Veereman G, et al. Hepatitis B in Patients with HIV Infection: Relationship to AIDS and Patient Survival. Ann Intern Med. 1992;117:837-838. doi: 10.7326/0003-4819-117-10-837
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Published: Ann Intern Med. 1992;117(10):837-838.
Hepatitis B virus (HBV) infection is common among persons with human immunodeficiency virus (HIV) infection (1-4). Hepatitis B virus DNA is found in lymphoid cells of patients co-infected with HBV and HIV (5), and studies in cultured cells co-infected or transfected with HIV and HBV DNA indicate that the HBV X gene product enhances HIV gene expression (6, 7). These findings suggest that infection with HBV may accelerate progression of HIV-related disease, but limited clinical information is available. Therefore, we retrospectively analyzed sera from 511 HIV-infected patients for evidence of hepatitis B, in order to examine the relationship between serologic
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