Theodore Wun, MD
Wun T. The Felty Syndrome and G-CSF-Associated Thrombocytopenia and Severe Anemia. Ann Intern Med. 1993;118:318-319. doi: 10.7326/0003-4819-118-4-199302150-00030
Download citation file:
Published: Ann Intern Med. 1993;118(4):318-319.
TO THE EDITOR:
The Felty syndrome is the triad of rheumatoid arthritis, splenomegaly, and neutropenia. The use of recombinant granulocyte-macrophage colony-stimulating factor (rGM-CSF) in patients with the Felty syndrome has yielded variable results [1, 2]. This is the second reported application of rG-CSF in a patient with the Felty syndrome .
A 51-year-old white man with seropositive rheumatoid arthritis and absolute neutrophil counts ranging from 0.055 to 0.2 × 109/L for 10 years was referred for frequent sinopulmonary and skin infections. Examination showed splenomegaly and stigmata of rheumatoid arthritis; bone marrow examination was hypercellular with a left-shifted myeloid line consistent with the Felty syndrome. Oral methotrexate, 2.5 mg, was given thrice weekly for 2 months without effect and was discontinued.
to gain full access to the content and tools.
Learn more about subscription options.
Register Now for a free account.
Copyright © 2016 American College of Physicians. All Rights Reserved.
Print ISSN: 0003-4819 | Online ISSN: 1539-3704
Conditions of Use
This PDF is available to Subscribers Only