Timothy F. Brewer, MD; Mary E. Wilson, MD; Harvey W. Fineberg, MD
Brewer T., Wilson M., Fineberg H.; Making the Blood Supply Safer. Ann Intern Med. 1993;118:574-575. doi: 10.7326/0003-4819-118-7-199304010-00034
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Published: Ann Intern Med. 1993;118(7):574-575.
Dr. Fuchs and colleagues advocate the use of a particular surrogate marker, neopterin, to protect recipients of blood products from infection. The usefulness of any test depends, in part, on its sensitivity, specificity, and costs. Evaluating a test's performance in detecting an unrecognized pathogen is complicated by the lack of a validated standard for the infection's presence or absence. In the case of testing blood products, costs include those related to discarding blood that would otherwise have been used, needing to find new donors, and implementing the test. If a donor notification program is used, additional emotional and medical costs would be incurred by those donors positive for the surrogate marker.
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Print ISSN: 0003-4819 | Online ISSN: 1539-3704
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