David B. Badesch, MD; Kristine M. Wynne, RN, BSN; Scott Bonvallet, MD; Norbert F. Voelkel, MD; Chester Ridgway, MD; Bertron M. Groves, MD
Badesch DB, Wynne KM, Bonvallet S, Voelkel NF, Ridgway C, Groves BM. Hypothyroidism and Primary Pulmonary Hypertension: An Autoimmune Pathogenetic Link?. Ann Intern Med. 1993;119:44-46. doi: 10.7326/0003-4819-119-1-199307010-00008
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Published: Ann Intern Med. 1993;119(1):44-46.
Primary pulmonary hypertension (PPH), an often fatal disease of unknown cause that primarily affects young women, is a diagnosis of exclusion. The relative roles of genetic predisposition, autoimmunity, viral infection, hormonal influences, and environmental and drug exposures are not known. Among seven patients enrolled by our center in a multicenter trial of continuous prostacyclin in severe PPH, four of the five women had hypothyroidism. Although a causal relationship cannot be established based on this small case series, the possibility of an autoimmune pathogenetic link between PPH and hypothyroidism should be investigated further.
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Endocrine and Metabolism, Pulmonary/Critical Care, Thyroid Disorders, Pulmonary Hypertension.
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Print ISSN: 0003-4819 | Online ISSN: 1539-3704
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