Dennis D. Taub, PhD; Kenneth J. Blank, PhD
Taub D., Blank K.; Superantigens and Microbial Pathogenesis. Ann Intern Med. 1993;119:89-90. doi: 10.7326/0003-4819-119-1-199307010-00016
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Published: Ann Intern Med. 1993;119(1):89-90.
The results of a randomized, controlled trial of endoscopic ligation of esophageal varices compared with sclerotherapy by Laine and colleagues, in this issue of Annals, is the second report of a relatively new endoscopic technique. The two techniques appear to be approximately comparable, except that the complication rate is less with ligation. Whether ligation will replace sclerotherapy remains to be seen.
Recent analysis of various bacterial and viral products has revealed that microbial proteins may be not only responsible for microbial infection and disease but also connected to the onset of autoimmunity. These microbial products are called superantigens because of their strong effect on the proliferation of certain T-lymphocyte populations. Superantigens elicit various biological activities, including lymphocyte mitogenesis, pyrogenicity, depressed antibody production, and shock [1, 2]. We describe the effects of microbial superantigens on immune function and their possible association with various acute and chronic inflammatory diseases.
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Infectious Disease, Rheumatology, Lupus Erythematosus, Rheumatoid Arthritis, Streptococcal Infections.
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Print ISSN: 0003-4819 | Online ISSN: 1539-3704
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