Ajay Anand, MD
Anand A.; Fibrinogen and Cardiovascular Risk. Ann Intern Med. 1993;119:1222-1223. doi: 10.7326/0003-4819-119-12-199312150-00015
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Published: Ann Intern Med. 1993;119(12):1222-1223.
TO THE EDITOR:
Drs. Ernst and Resch  present a comprehensive review of the role of fibrinogen as a cardiovascular risk factor. They delineate possible mechanisms by which fibrinogen may promote atherosclerosis and thrombosis. In one study  of fibrin gel network characteristics and plasma fibrinogen in patients who had a myocardial infarction before the age of 45 years, those with an increased plasma fibrinogen concentration had a lower fibrin gel porosity than either patients with normal plasma fibrinogen levels or controls. This suggests that a propensity to form tight, rigid, and space-filling fibrin network structures with small pores may be associated with premature coronary artery disease. Munkvad and coworkers  found that the plasma concentrations of clottable fibrinogen and high-molecular-weight fibrinogen were related to the development of myocardial infarction in patients with coronary disease. A positive correlation of clottable fibrinogen and high-molecular-weight fibrinogen was shown (r = 0.58, P < 0.001), implying that high-molecular-weight fibrinogen represents a major percentage of the clottable fibrinogen concentration in patients with coronary ischemia.
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Print ISSN: 0003-4819 | Online ISSN: 1539-3704
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