Edzard Ernst, MD; Karl Ludwig Resch, MD
Ernst E, Resch KL. Fibrinogen and Cardiovascular Risk. Ann Intern Med. 1993;119:1222-1223. doi: 10.7326/0003-4819-119-12-199312150-00016
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Published: Ann Intern Med. 1993;119(12):1222-1223.
Several points raised in this letter are relevant. The pharmacologic alteration of fibrinogen seems a grossly under-researched area. Many drugs influence the alteration but often it is difficult to determine if it results from the drug's effect on a given disorder or is a direct effect of the drug itself.
That fibrinogen levels increase in intermittent claudication has been observed repeatedly. Recently, Lowe and coworkers  reported epidemiologic data showing that the increase is independently associated with peripheral arterial narrowing. Thus, a prognostic relevance of fibrinogen in peripheral arterial occlusive disease comes as little surprise, particularly when considering that it is of prognostic value in atherosclerosis of other major vascular trees, as shown in our meta-analysis .
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