Louis J. Papa, MD
Papa L.; Treatment of Nongonococcal Urethritis. Ann Intern Med. 1993;119:1226. doi: 10.7326/0003-4819-119-12-199312150-00026
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Published: Ann Intern Med. 1993;119(12):1226.
TO THE EDITOR:
The study by Romanowski and associates  regarding the efficacy of minocycline in the treatment of nongonococcal urethritis and mucopurulent cervicitis leaves me confused. Their results appear to support the hypothesis that minocycline is as effective as doxycycline, but it seems a bit premature to suggest that their findings support the administration of minocycline 100 mg as a single nightly dose over doxycycline .
The crux of their recommendation may be based on improved compliance. This factor was not evaluated in their study. Their recommendation may be based on the fewer side effects seen with minocycline. However, side effects were specifically elicited, and, although a grading system was used to measure their severity, this system was not applied when comparing the minocycline and doxycycline groups.
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