Gloria Gridley, MS; John H. Klippel, MD; Robert N. Hoover, MD; Joseph F. Fraumeni Jr., MD
To estimate the incidence of cancer (especially lymphoproliferative malignancies) in patients with the Felty syndrome.
A retrospective cohort study.
A computerized database of all discharge records for 1969 to 1990 from a Veterans Affairs hospital.
906 men with a discharge diagnosis of the Felty syndrome.
Standardized incidence ratios (SIR) (ratios of observed-to-expected events) estimated the risk for specific cancers. Hospital records confirmed the diagnoses of the Felty syndrome and cancer.
We observed a twofold increase in total cancer incidence (137 patients; SIR = 2.09; 95% CI, 1.8 to 2.5). The risk for non-Hodgkin lymphoma (19 patients; SIR = 12.8, CI, 7.7 to 20.0) was much greater than the twofold increase in risk for lymphoma generally reported for rheumatoid arthritis. The risk for leukemia was increased but only within 5 years of the first hospitalization for the Felty syndrome, (13 patients; SIR = 7.67; CI, 4.1 to 13.1).
The increased risk for non-Hodgkin lymphoma after the Felty syndrome in our study is similar to the risk associated with the Sjogren syndrome and may reflect similar immunostimulatory mechanisms.
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Gridley G, Klippel JH, Hoover RN, Fraumeni JF. Incidence of Cancer among Men with the Felty Syndrome. Ann Intern Med. 1994;120:35–39. doi: 10.7326/0003-4819-120-1-199401010-00006
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Published: Ann Intern Med. 1994;120(1):35-39.
Hematology/Oncology, Rheumatoid Arthritis, Rheumatology.
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Print ISSN: 0003-4819 | Online ISSN: 1539-3704
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