Khin Mae Hla, MD, MHS; Terry B. Young, PhD; Tom Bidwell, MS; Mari Palta, PhD; James B. Skatrud, MD; Jerome Dempsey, PhD
Hla KM, Young TB, Bidwell T, Palta M, Skatrud JB, Dempsey J. Sleep Apnea and Hypertension: A Population-based Study. Ann Intern Med. 1994;120:382-388. doi: 10.7326/0003-4819-120-5-199403010-00005
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Published: Ann Intern Med. 1994;120(5):382-388.
To measure the independent association of sleep-disordered breathing (sleep apnea and habitual snoring) and hypertension in a healthy adult population.
A cross-sectional study of blood pressure during wakefulness and sleep among participants with and without sleep-disordered breathing.
147 men and women, aged 30 to 60 years, selected from Wisconsin State employees enrolled in the Wisconsin Sleep Cohort Study, an ongoing, prospective, epidemiologic study of sleep-disordered breathing.
Sleep and medical history interview, nocturnal polysomnography, and 24-hour ambulatory blood pressure monitoring in all participants.
Mean blood pressures were significantly higher among participants with sleep apnea (≥ 5 apneas or hypopneas per hour of sleep) compared with those without (131/80 ±1.7/1.1 mm Hg compared with 122/75 ±1.9/1.2 mm Hg during wakefulness and 113/66 ±1.8/1.1 mm Hg compared with 104/62 ±2/1.3 mm Hg during sleep, respectively; P < 0.05). The variability of the blood pressure during sleep was significantly greater in participants with sleep apnea or a history of snoring compared with those without (P < 0.05). After controlling for obesity, age, and sex, sleep apnea was significantly associated with hypertension in a dose-response fashion, with odds ratios ranging from 2.0 for 5 apneic or hypopneic episodes per hour of sleep to 5.0 for 25 apneic or hypopneic episodes.
Our data indicate an association between hypertension and sleep apnea independent of obesity, age, and sex in a nonselected, community-based adult population.
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Cardiology, Nephrology, Pulmonary/Critical Care, Hypertension, Coronary Risk Factors.
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Print ISSN: 0003-4819 | Online ISSN: 1539-3704
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