Joshua H. Lipschutz, MD; Allen I. Arieff, MD
Lipschutz JH, Arieff AI. Reset Osmostat in a Healthy Patient. Ann Intern Med. 1994;120:574-576. doi: 10.7326/0003-4819-120-7-199404010-00007
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Published: Ann Intern Med. 1994;120(7):574-576.
Reset osmostat is a rare condition in acutely ill patients with severe pulmonary [1, 2], neurologic [3, 4], or malignant processes . When hyponatremia occurs because of “reset osmostat,” renal concentrating and diluting capacities are normal but the regulation of arginine vasopressin to maintain serum tonicity takes place at a lower osmolal threshold.
We report chronic stable hyponatremia secondary to reset osmostat in a healthy middle-aged man who had sustained a grenade explosion to his face 41 years earlier.
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Endocrine and Metabolism, Nephrology, Fluid and Electrolyte Disorders.
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Print ISSN: 0003-4819 | Online ISSN: 1539-3704
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