Pankaj J. Pasricha, MD; William J. Ravich, MD; Thomas R. Hendrix, MD; Samuel Sostre, MD; Bronwyn Jones, MD; Anthony N. Kalloo, MD
Pasricha P., Ravich W., Hendrix T., Sostre S., Jones B., Kalloo A.; Treatment of Achalasia with Intrasphincteric Injection of Botulinum Toxin: A Pilot Trial. Ann Intern Med. 1994;121:590-591. doi: 10.7326/0003-4819-121-8-199410150-00006
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Published: Ann Intern Med. 1994;121(8):590-591.
Achalasia is a disorder characterized by a failure of the lower esophageal sphincter to relax with swallowing and by a lack of esophageal peristalsis. The sphincteric abnormalities in achalasia are thought to be caused by a selective loss of inhibitory neurons in the myenteric plexus, resulting in the relatively unopposed excitation of the smooth muscle by acetylcholine and other mediators. Our previous studies in animals  have shown that locally injected botulinum toxin, a potent inhibitor of acetylcholine release, can reduce lower esophageal sphincter tone. We report our initial experience with this agent for the treatment of achalasia in humans.
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Gastroenterology/Hepatology, Esophageal Disorders.
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Print ISSN: 0003-4819 | Online ISSN: 1539-3704
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