Rajat Mathur, MD, MRCP; Neil J. Douglas, MD, ChB, MD, FRCP
Mathur R, Douglas NJ. Family Studies in Patients with the Sleep Apnea-Hypopnea Syndrome. Ann Intern Med. 1995;122:174-178. doi: 10.7326/0003-4819-122-3-199502010-00003
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Published: Ann Intern Med. 1995;122(3):174-178.
To determine whether familial factors affect development of the sleep apnea–hypopnea syndrome and upper airway caliber.
A case–control study.
Tertiary, referral clinical sleep laboratory.
51 first-degree relatives of patients with the sleep apnea–hypopnea syndrome and 51 controls matched for age, sex, height, and weight who were drawn at random from a family practice register. To avoid studying the familial nature of obesity, only relatives of index patients with body mass indices less than 30.0 kg/m2 were recruited.
Assessment of sleep-related symptoms; breathing, sleep, and oxygenation patterns on overnight polysomnograms; upper airway dimensions by acoustic reflection; and facial structure by lateral cephalometry.
More relatives of patients with the sleep apnea–hypopnea syndrome reported snoring (24 relatives compared with 7 controls; P < 0.001) and daytime sleepiness (28 relatives compared with 16 controls; P = 0.01). Relatives had more apneas and hypopneas per hour (median of 13/h [95% CI, 3 to 82/h] for relatives compared with median of 4/h [CI, 0 to 53/h] for controls; P < 0.001), more arousals from sleep (30/h [CI, 11 to 87/h] for relatives compared with 17/h [CI, 4 to 59/h] for controls; P <0.001), poorer sleep quality, and more oxygen desaturations. Relatives also had narrower upper airways with retroposed maxillae and mandibles and longer soft palates with wider uvulae.
The sleep apnea–hypopnea syndrome has a strong familial component. The familial tendency may be caused by differences in facial structure.
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Pulmonary/Critical Care, Sleep Disorders.
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Print ISSN: 0003-4819 | Online ISSN: 1539-3704
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