Michael Augenbraun, MD; Joseph Feldman, DrPH; Keith Chirgwin, MD; Jonathan Zenilman, MD; Lorraine Clarke, PhD; Jack DeHovitz, MD, MPH; Sheldon Landesman, MD; Howard Minkoff, MD
To compare the prevalence of genital herpes simplex virus type 2 (HSV-2) shedding in human immunodeficiency virus (HIV)-seropositive women and HIV-seronegative women.
A major inner-city medical center.
106 women who were HIV-seropositive and HSV-2-seropositive and 70 women who were HIV-seronegative and HSV-2-seropositive were enrolled from various primary care settings.
Herpes simplex virus type 2 antibody determinations were done for all patients. Regardless of symptoms, vulvar and cervical HSV cultures were obtained from all HIV-seropositive women and from a randomly selected subgroup of HIV-seronegative women.
The prevalence of HSV-2 shedding was nearly four times greater in HIV-seropositive than in HIV-seronegative women (13.2% compared with 3.6%; P = 0.04; odds ratio, 4.1 [95% CI, 1.0 to 27.4]) when the serum antibody for HSV-2 was present. Seventy-nine percent of viral shedding among HIV-seropositive women was asymptomatic. Overall viral shedding increased significantly as the CD4 cell count decreased.
Women with HIV infection, particularly those with low CD4 cell counts, shed HSV-2 from the vulva and cervix more commonly than women not infected with HIV. Most of this shedding is asymptomatic.
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Augenbraun M, Feldman J, Chirgwin K, Zenilman J, Clarke L, DeHovitz J, et al. Increased Genital Shedding of Herpes Simplex Virus Type 2 in HIV-Seropositive Women. Ann Intern Med. 1995;123:845–847. doi: 10.7326/0003-4819-123-11-199512010-00006
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Published: Ann Intern Med. 1995;123(11):845-847.
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Print ISSN: 0003-4819 | Online ISSN: 1539-3704
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