Donald Kaye, MD
Kaye D. Treatment of Infective Endocarditis. Ann Intern Med. 1996;124:606-608. doi: 10.7326/0003-4819-124-6-199603150-00011
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Published: Ann Intern Med. 1996;124(6):606-608.
The American Heart Association's recently published recommendations for treating infective endocarditis  contain many substantial changes from the previous version .
The first major change is the addition of a regimen suitable for outpatient treatment of infective endocarditis in patients with strains of streptococci that are highly susceptible to penicillin. This regimen consists of ceftriaxone, 2 g administered intravenously or intramuscularly once daily for 4 weeks. In the past, outpatient treatment with oral agents was not advocated because of the possibility of variable absorption of agents and lack of patient compliance. Furthermore, the previously used parenteral regimens for home therapy required two or three daily injections. The long half-life of ceftriaxone, which permits once-daily injection, is a major advantage in terms of cost and convenience. The daily injection can be given by a visiting nurse or family member in the home or can be given at a physician's office or an emergency department. An intravenous central line catheter may be required. Home therapy should be reserved for hemodynamically stable patients who have no complications of endocarditis.
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Cardiology, Infectious Disease, Endocarditis.
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Print ISSN: 0003-4819 | Online ISSN: 1539-3704
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