Henry Masur, MD; Scott M. Whitcup, MD; Charles Cartwright, PhD; Michael Polis, MD; Robert Nussenblatt, MD
Masur H, Whitcup SM, Cartwright C, Polis M, Nussenblatt R. Advances in the Management of AIDS-Related Cytomegalovirus Retinitis. Ann Intern Med. 1996;125:126-136. doi: 10.7326/0003-4819-125-2-199607150-00009
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Published: Ann Intern Med. 1996;125(2):126-136.
Cytomegalovirus (CMV) retinitis, a common complication of the acquired immunodeficiency syndrome (AIDS), is increasing in frequency as patients infected with the human immunodeficiency virus (HIV) live longer.In recent years, the lifetime risk for CMV disease in HIV-infected persons has increased from 24.9% to 44.9%. Cytomegalovirus retinitis is usually diagnosed clinically: Almost all patients are CMV seropositive and have CD4+ counts less than 50 cells/mm3. Specific diagnostic tests that use antigen detection or quantitation of circulating nucleic acid to detect CMV are being developed, but they have not been validated for routine clinical use. Such tests would help predict disease, diagnose acute retinitis, and monitor therapy.
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