Andreas Creutzig, MD; Carsten Ranke, MD
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Creutzig A., Ranke C.; Aspirin for Asymptomatic Carotid Artery Stenosis. Ann Intern Med. 1996;125:420. doi: 10.7326/0003-4819-125-5-199609010-00016
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Published: Ann Intern Med. 1996;125(5):420.
TO THE EDITOR:
Cote and colleagues  present strong evidence that aspirin, 325 mg/d, does not effectively prevent ischemic events in asymptomatic patients with high-grade (≥ 50%) carotid artery stenosis .
In a prospective, double-blind trial , we showed that aspirin treatment slows the growth of carotid plaque in a dose-dependent fashion; a dose of 900 mg/d was more efficient than 50 mg/d . Twenty-seven asymptomatic patients with 104 small carotid atheroma (<50% lumen narrowing) received aspirin for 1 year; during that period they were examined with a high-resolution ultrasound duplex system. The change in plaque area was significantly different for the treatment groups: Average plaque size remained the same after treatment with 900 mg of aspirin daily but increased markedly after treatment with 50 mg of aspirin daily (P = 0.011). There were significantly more lesions that showed progression in the 50-mg group than in the 900-mg group. Ultrasonographically proven disappearance of a lesion was noted only in the 900-mg group.
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Print ISSN: 0003-4819 | Online ISSN: 1539-3704
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