James A. Strauchen, MD; A. Daniel Hauser, MD; David Burstein, MD; Ricardo Jimenez, MD; Patrick S. Moore, MD; Yuan Chang, MD
Strauchen JA, Hauser AD, Burstein D, Jimenez R, Moore PS, Chang Y. Body Cavity-Based Malignant Lymphoma Containing Kaposi Sarcoma-Associated Herpesvirus in an HIV-Negative Man with Previous Kaposi Sarcoma. Ann Intern Med. 1996;125:822-825. doi: 10.7326/0003-4819-125-10-199611150-00006
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Published: Ann Intern Med. 1996;125(10):822-825.
The role of Kaposi sarcoma-associated herpesvirus in the development of malignant lymphomas in patients negative for the human immunodeficiency virus (HIV) has not been established.
To examine the possible role of Kaposi sarcoma-associated herpesvirus in a case of body cavity-based malignant lymphoma that occurred in an HIV-negative patient who had previously had Kaposi sarcoma.
Academic medical center.
A 94-year-old man with lymphomatous ascites.
Polymerase chain reaction (PCR) and Southern blot DNA analysis.
The body cavity-based lymphoma cells were positive for Kaposi sarcoma-associated herpesvirus by PCR and were negative for other herpesviruses, including Epstein-Barr virus, cytomegalovirus, and human herpesviruses 6 and 7. Southern blot analysis of lymphoma DNA showed high levels of Kaposi sarcoma-associated herpesvirus (>40 to 80 genomes/cell). Clonal rearrangement of the immunoglobulin JH and JK genes was present, confirming the presence of a clonal B-cell proliferation.
Kaposi sarcoma-associated herpesvirus may be involved in the development of malignant lymphoma after Kaposi sarcoma in HIV-negative patients. This type of lymphoma, in contrast to body cavity-based lymphoma related to the acquired immunodeficiency syndrome, may have an indolent clinical course.
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Hematology/Oncology, Infectious Disease.
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Print ISSN: 0003-4819 | Online ISSN: 1539-3704
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