Joseph M. Guattery, MD; William W. Faloon, MD; Daniel L. Biery, DO
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Guattery J., Faloon W., Biery D.; Effect of Ethinyl Estradiol on Chronic Active Hepatitis. Ann Intern Med. 1997;126:88. doi: 10.7326/0003-4819-126-1-199701010-00019
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Published: Ann Intern Med. 1997;126(1):88.
[This letter was originally published in the 15 October 1996 issue of Annals. The accompanying figure (Figure 1) was inadvertently omitted from that issue.]
TO THE EDITOR:
A decrease in serum liver enzyme levels in patients with primary biliary cirrhosis during treatment with ethinyl estradiol  led to a study of this drug in six women with chronic inflammatory liver disease. Patient ages ranged from 28 to 72 years (mean, 60 years). All aspartate aminotransferase and other serum enzyme levels were greater than twice the normal level for more than 6 months. Examination of liver biopsy specimens showed inflammation, piecemeal necrosis, or fibrosis. One patient was positive for the antibody to hepatitis C virus, 1 had autoimmune chronic active hepatitis, 1 was positive for hepatitis B surface antigen and hepatitis e antigen, and 3 had cryptogenic hepatitis. Patients were studied for 6 months to 7 years.
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Print ISSN: 0003-4819 | Online ISSN: 1539-3704
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