David S. Pisetsky, MD, PhD
Pisetsky DS. DNA and the Immune System. Ann Intern Med. 1997;126:169-171. doi: 10.7326/0003-4819-126-2-199701150-00015
Download citation file:
Published: Ann Intern Med. 1997;126(2):169-171.
Deoxyribonucleic acid (DNA) conveys an enormous amount of information because of the myriad ways in which its four bases can be arranged. As a genetic blueprint, this information provides elaborate instructions for the structure of proteins and the regulation of their expression. Encoded in DNA, however, is information of a fundamentally different kind. As provocative new data indicate, DNA from bacteria has sequences that can instruct the immune system to distinguish “foreign” from “self.” These sequences, which bear characteristic motifs, can trigger innate immunity and are important not only in host defense but in the burgeoning use of DNA to prevent and treat disease .
to gain full access to the content and tools.
Learn more about subscription options.
Register Now for a free account.
Infectious Disease, Rheumatology, Lupus Erythematosus, Vaccines/Immunization, Prevention/Screening.
Results provided by:
Copyright © 2016 American College of Physicians. All Rights Reserved.
Print ISSN: 0003-4819 | Online ISSN: 1539-3704
Conditions of Use
This PDF is available to Subscribers Only