Eveline P. Mauser-Bunschoten, MD, PhD; Marjolein Damen, MD; H. Marijke van den Berg, MD, PhD
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Mauser-Bunschoten E., Damen M., van den Berg H.; Interferon-α Treatment and Formation of Factor VIII Antibodies. Ann Intern Med. 1997;126:829-830. doi: 10.7326/0003-4819-126-10-199705150-00025
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Published: Ann Intern Med. 1997;126(10):829-830.
Dr. Stricker states that if no patients with mild hemophilia were included in our study, the conclusion should be that interferon-α therapy for chronic hepatitis C is not associated with alloantibody formation in patients with severe hemophilia. Indeed, we agree with this conclusion because the interferon-α group included only one patient with mild hemophilia. Most patients with severe hemophilia who received clotting factor concentrate before 1991 are infected with hepatitis C virus and need antiviral treatment (including interferon-α); thus, the conclusion of our study is of importance for such patients. The patient in our study who had clinical evidence of a factor VIII inhibitor during interferon-α therapy also had severe hemophilia.
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