Elio Castagnola, MD; Claudio Viscoli, MD
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Castagnola E, Viscoli C. Gram-Positive Infections and Quinolones in Neutropenia. Ann Intern Med. 1997;126:830-831. doi: 10.7326/0003-4819-126-10-199705150-00027
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Published: Ann Intern Med. 1997;126(10):830-831.
TO THE EDITOR:
In their recent report, Bow and colleagues  suggest that prophylaxis with fluoroquinolones and rifampin in neutropenic patients decreases the incidence of gram-negative bacteremias and the overall number of documented infections. However, prophylaxis did not reduce the number of febrile episodes or the use of intravenous antibiotics and did not affect either the final outcome of febrile episodes that occurred despite prophylaxis or the overall mortality rate. Although the statistical power of the observed results is not clear (surprisingly, the manner in which the sample size was calculated was not explained), these results deserve some comments, especially about the conclusions one should draw from this article.
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