Mark A. Marinella, MD; Richard H. Moseley, MD
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Marinella MA, Moseley RH. Hepatitis C and Cancer. Ann Intern Med. 1997;126:1002-1003. doi: 10.7326/0003-4819-126-12-199706150-00022
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Published: Ann Intern Med. 1997;126(12):1002-1003.
TO THE EDITOR:
We read with interest the recent review article by Sharara and coworkers . The authors mention the role of hepatitis C virus (HCV) in the pathogenesis of hepatocellular carcinoma and note that HCV does not integrate into the host genome. Chronic HCV infection has also been implicated in various autoimmune phenomenon, including essential mixed cryoglobulinemia, membranoproliferative glomerulonephritis, porphyria cutanea tarda, and autoimmune thyroiditis . Hepatitis C virus is a lymphotrophic virus that supports the association between chronic HCV infection and the clonal B-cell proliferation that occurs with mixed cryoglobulinemia . Recently, HCV was reported to be a risk factor for the development of non-Hodgkin B-cell lymphoma, notably low-grade lymphoma [3, 4]. Ferri and colleagues  have detected markers to HCV in as many as 33% of unselected patients with non-Hodgkin B-cell lymphoma.
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Print ISSN: 0003-4819 | Online ISSN: 1539-3704
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