Luisa Fernandez-Soto, MD; Amalia Gonzalez-Jimenez, MD; Fernando Escobar-Jimenez, MD
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Fernandez-Soto L., Gonzalez-Jimenez A., Escobar-Jimenez F.; Smoking and Autoimmune Thyroid Disease. Ann Intern Med. 1997;126:1005. doi: 10.7326/0003-4819-126-12-199706150-00029
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Published: Ann Intern Med. 1997;126(12):1005.
TO THE EDITOR:
Evidence increasingly suggests that smoking has an effect on autoimmune thyroid disease. In particular, smoking has been shown to worsen Graves disease and Graves ophthalmopathy . The exact role of smoking on the autoimmune mechanism is unclear, but smoking is known to have an antithyroid effect [2, 3]. We investigated antithyroid peroxidase antibodies (TPO-Ab) and antithyroglobulin antibodies (Tg-Ab) in a large cohort of healthy pregnant women before 16 weeks of gestation (n = 349). Levels of TPO-Ab were significantly increased (P < 0.001) in the 32 women who smoked more than 10 cigarettes per day before gestation compared with the 73 women who smoked fewer than 10 cigarettes per day (718 ± 659 U/mL and 101 ± 34 U/mL, respectively) or the 244 women who were nonsmokers (99 ± 22 U/mL). Levels of Tg-Ab were significantly increased (P = 0.009) in pregnant women who smoked more than 10 cigarettes per day compared with those who smoked fewer than 10 cigarettes per day (125 ± 105 U/mL and 37 ± 16 U/mL, respectively) or those who were nonsmokers (31 ± 4 U/mL).
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Print ISSN: 0003-4819 | Online ISSN: 1539-3704
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