John Nowakowski, MD; Ira Schwartz, PhD; Robert B. Nadelman, MD; Dionysios Liveris, PhD; Maria Aguero-Rosenfeld, MD; Gary P. Wormser, MD
Nowakowski J, Schwartz I, Nadelman RB, Liveris D, Aguero-Rosenfeld M, Wormser GP. Culture-Confirmed Infection and Reinfection with Borrelia burgdorferi. Ann Intern Med. 1997;127:130-132. doi: 10.7326/0003-4819-127-2-199707150-00006
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Published: Ann Intern Med. 1997;127(2):130-132.
Lyme disease, the most common vector-borne disease in the United States, is caused by infection with the spirochete Borrelia burgdorferi. Reinfection has been described clinically but has not been substantiated microbiologically [2-5]. We documented the occurrence of reinfection by isolating B. burgdorferi during two different clinical episodes of Lyme disease. Polymerase chain reaction (PCR)-restriction fragment length polymorphism analysis of the two isolates showed that the isolates were different strains of B. burgdorferi, suggesting reinfection and not reactivation of a previous infection. We also used enzyme-linked immunosorbent assay (ELISA) and immunoblot to evaluate the antibody response of sequential blood samples to B. burgdorferi.
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Print ISSN: 0003-4819 | Online ISSN: 1539-3704
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