John S. Adams, MD; Gene Lee
Adams J., Lee G.; Gains in Bone Mineral Density with Resolution of Vitamin D Intoxication. Ann Intern Med. 1997;127:203-206. doi: 10.7326/0003-4819-127-3-199708010-00004
Download citation file:
Published: Ann Intern Med. 1997;127(3):203-206.
Vitamin D intoxication is associated with the mobilization of skeletal calcium.
To ascertain how the resolution of vitamin D intoxication affects bone density.
Referral service for metabolic bone disease in a tertiary care teaching hospital.
Four patients with osteoporosis who were each using several nonprescription dietary supplements and were found to have fasting hypercalciuria.
Discontinuation of use of dietary supplements.
Serial measurement of serum levels of 25-hydroxyvitamin D, ratio of fasting urinary calcium to creatinine, and bone mineral density for 3 years.
Discontinuation of use of dietary supplements resulted in the normalization of serum levels of 25-hydroxyvitamin D, the normalization of the ratio of urinary calcium to creatinine, and a mean annual increase in bone mineral density (±SD) of 1.9% ± 0.6%.
Occult vitamin D intoxication was detected in patients who were using dietary supplements that contained an unadvertised high level of vitamin D. Resolution of vitamin D intoxication was associated with a rebound in bone mineral density.
Barbara Z Kravets CCN LDN
March 15, 2007
Questions regarding levels of 25 OH D and 1, 25 OH D and PTH
Dear Sirs: In re: your article Gains in Bone Mineral Density with Resolution of Vitamin D Intoxication
John S. Adams, MD, and Gene Lee
1 August 1997 | Volume 127 Issue 3 | Pages 203-206 in Annals of Internal Medicine.
Thank you for your interesting article. However, I would appreciate if you could answer questions for me:
1) What was the level of Vitamin D consumed? Two sententences, as below, are confusing.
"No patient knowingly consumed more than 1200 IU of vitamin D daily or took other medications known to alter skeletal metabolism."
"Some of these products were advertised as containing as much as 3600 IU of vitamin D3 per daily dosage"
2) What were the measured levels of 25 OH D3 and 1,25 OH D3 and 25 OH D2?
3) What was the measured level of Parathyroid Hormone?
4) Was was the animal extract product?.
5) What was the level of Calcium measured?
Thank you for your attention to my questions.
Barbara Zeitlin Kravets CCN LDN
to gain full access to the content and tools.
Learn more about subscription options.
Register Now for a free account.
Emergency Medicine, Endocrine and Metabolism, Metabolic Bone Disorders.
Results provided by:
Copyright © 2016 American College of Physicians. All Rights Reserved.
Print ISSN: 0003-4819 | Online ISSN: 1539-3704
Conditions of Use
This PDF is available to Subscribers Only