John S. Adams, MD; Gene Lee
Adams JS, Lee G. Gains in Bone Mineral Density with Resolution of Vitamin D Intoxication. Ann Intern Med. 1997;127:203-206. doi: 10.7326/0003-4819-127-3-199708010-00004
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Published: Ann Intern Med. 1997;127(3):203-206.
Vitamin D intoxication is associated with the mobilization of skeletal calcium.
To ascertain how the resolution of vitamin D intoxication affects bone density.
Referral service for metabolic bone disease in a tertiary care teaching hospital.
Four patients with osteoporosis who were each using several nonprescription dietary supplements and were found to have fasting hypercalciuria.
Discontinuation of use of dietary supplements.
Serial measurement of serum levels of 25-hydroxyvitamin D, ratio of fasting urinary calcium to creatinine, and bone mineral density for 3 years.
Discontinuation of use of dietary supplements resulted in the normalization of serum levels of 25-hydroxyvitamin D, the normalization of the ratio of urinary calcium to creatinine, and a mean annual increase in bone mineral density (±SD) of 1.9% ± 0.6%.
Occult vitamin D intoxication was detected in patients who were using dietary supplements that contained an unadvertised high level of vitamin D. Resolution of vitamin D intoxication was associated with a rebound in bone mineral density.
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Emergency Medicine, Endocrine and Metabolism, Metabolic Bone Disorders.
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Print ISSN: 0003-4819 | Online ISSN: 1539-3704
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