Caroline Breese Hall, MD
Hall CB. Human Herpesviruses at Sixes, Sevens, and More. Ann Intern Med. 1997;127:481-483. doi: 10.7326/0003-4819-127-6-199709150-00010
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Published: Ann Intern Med. 1997;127(6):481-483.
In the past decade, the family circle of human herpesviruses (HHVs) has expanded to include three new numbers: HHV-6, −7,and −8.Although each was initially discovered in adults, their reputation, relevance, and renitence begin in infancy.
Techniques developed to study HIV infection revealed the existence of HHV-6. Initially found in the lymphocytes of patients with AIDS and lymphoproliferative diseases, this novel virus bore a familial resemblance to the herpesviruses and was adopted as their sixth member . Composed of a large double-stranded DNA, DNA polymerase (but not thymidine kinase), and several important glycoproteins, HHV-6 can infect many types of cell but, like HIV, primarily affects CD4 cells. As with other herpesviruses, persistence or latency occurs; genomic material can then be detected in peripheral blood lymphocytes, secretions, and cerebrospinal fluid in healthy and immunosuppressed persons.
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Print ISSN: 0003-4819 | Online ISSN: 1539-3704
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