Petra E. Steindl, MD; Peter Ferenci, MD; Wolfgang Marktl, MD
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Steindl PE, Ferenci P, Marktl W. Impaired Hepatic Catabolism of Melatonin in Cirrhosis. Ann Intern Med. 1997;127:494. doi: 10.7326/0003-4819-127-6-199709150-00025
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Published: Ann Intern Med. 1997;127(6):494.
TO THE EDITOR:
Prompted by Garfinkel and Zisapel's comment  on our paper, published in August 1995 , we present some consecutive data. We postulated that elevated plasma melatonin levels and an altered 24-hour profile of the hormone we found in patients with liver cirrhosis  could represent an altered output of the circadian clock , causing a central disturbance of circadian rhythmicity.
Garfinkel and Zisapel suggested that we measure the urinary metabolite of melatonin, 6-sulfatoxymelatonin, to determine whether increased production in the pineal gland or decreased catabolism by the liver is the main reason for elevated serum melatonin levels in patients with liver cirrhosis.
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Print ISSN: 0003-4819 | Online ISSN: 1539-3704
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