Shu-ichi Ikeda, MD; Yo-ichi Takei, MD; Nobuo Yanagisawa, MD; Hidetoshi Matsunami, MD; Yasuhiko Hashikura, MD; Toshihiko Ikegami, MD; Seiji Kawasaki, MD
Ikeda S, Takei Y, Yanagisawa N, Matsunami H, Hashikura Y, Ikegami T, et al. Peripheral Nerves Regenerated in Familial Amyloid Polyneuropathy after Liver Transplantation. Ann Intern Med. 1997;127:618-620. doi: 10.7326/0003-4819-127-8_Part_1-199710150-00006
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Published: Ann Intern Med. 1997;127(8_Part_1):618-620.
Liver transplantation holds promise as a treatment for familial amyloid polyneuropathy.
To determine whether peripheral nerves regenerate in patients with familial amyloid polyneuropathy after liver transplantation.
University hospital in Matsumoto, Japan.
A 34-year-old woman with familial amyloid polyneuropathy who had liver transplantation and showed marked clinical improvement 3 years after surgery.
Histopathologic examination and morphometric analysis of biopsy specimens taken from sural nerves.
Diffuse fiber loss and amyloid deposits were seen in a biopsy specimen of the left sural nerve obtained before liver transplantation (total number of myelinated fibers, 1326/mm2 of the endoneurial area). In the biopsy specimen of the right sural nerve, which was obtained 3 years after transplantation, amyloid deposits remained but the number of myelinated fibers was markedly increased (total number of myelinated fibers, 4740/mm2).
Peripheral nerves regenerated in a patient with familial amyloid polyneuropathy after liver transplantation.
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Gastroenterology/Hepatology, Neurology, Neuropathy, Liver Transplantation, Liver Disease.
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Print ISSN: 0003-4819 | Online ISSN: 1539-3704
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