Shu-ichi Ikeda, MD; Yo-ichi Takei, MD; Nobuo Yanagisawa, MD; Hidetoshi Matsunami, MD; Yasuhiko Hashikura, MD; Toshihiko Ikegami, MD; Seiji Kawasaki, MD
Liver transplantation holds promise as a treatment for familial amyloid polyneuropathy.
To determine whether peripheral nerves regenerate in patients with familial amyloid polyneuropathy after liver transplantation.
University hospital in Matsumoto, Japan.
A 34-year-old woman with familial amyloid polyneuropathy who had liver transplantation and showed marked clinical improvement 3 years after surgery.
Histopathologic examination and morphometric analysis of biopsy specimens taken from sural nerves.
Diffuse fiber loss and amyloid deposits were seen in a biopsy specimen of the left sural nerve obtained before liver transplantation (total number of myelinated fibers, 1326/mm2 of the endoneurial area). In the biopsy specimen of the right sural nerve, which was obtained 3 years after transplantation, amyloid deposits remained but the number of myelinated fibers was markedly increased (total number of myelinated fibers, 4740/mm2).
Peripheral nerves regenerated in a patient with familial amyloid polyneuropathy after liver transplantation.
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Ikeda S, Takei Y, Yanagisawa N, Matsunami H, Hashikura Y, Ikegami T, et al. Peripheral Nerves Regenerated in Familial Amyloid Polyneuropathy after Liver Transplantation. Ann Intern Med. 1997;127:618-620. doi: 10.7326/0003-4819-127-8_Part_1-199710150-00006
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Published: Ann Intern Med. 1997;127(8_Part_1):618-620.
Gastroenterology/Hepatology, Liver Disease, Liver Transplantation, Neurology, Neuropathy.
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Print ISSN: 0003-4819 | Online ISSN: 1539-3704
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