H. Jakob Michenfelder, MD; Jennifer Thompson, MD; Mark Shepherd, MD
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Michenfelder H., Thompson J., Shepherd M.; Over-the-Counter Chromium and Renal Failure. Ann Intern Med. 1997;127:655. doi: 10.7326/0003-4819-127-8_Part_1-199710150-00026
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Published: Ann Intern Med. 1997;127(8_Part_1):655.
TO THE EDITOR:
In a recent letter, Wasser and colleagues  state that intake of chromium picolinate can lead to chronic interstitial nephritis. They cite the case of a woman with unexpected chronic renal failure, biopsy-proven chronic interstitial nephritis, and documented normal renal function 2 years earlier who had taken 600 µg of chromium picolinate for 6 weeks 5 months before the diagnosis of chronic renal failure.
We strongly disagree with the authors' conclusion. Chronic interstitial nephritis can have many causes ; the temporal relation of the discovery of the chronic renal failure and the intake of chromium picolinate does not prove a causal relation. One of the cited references , by using controversial data and hypotheses , predicts that 600 µg of chromium picolinate taken daily for 5 years could result in tissue accumulation of chromium levels that may be cytotoxic and genotoxic. Even if this controversial model is correct, it does not provide sufficient grounds to postulate that 600 µg of chromium picolinate taken daily for 6 weeks could result in nephrotoxicity.
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Print ISSN: 0003-4819 | Online ISSN: 1539-3704
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