Wendell A. Wilson, MD; Azzudin E. Gharavi, MD
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Wilson W., Gharavi A.; Hypercoagulable States. Ann Intern Med. 1997;127:1128. doi: 10.7326/0003-4819-127-12-199712150-00015
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Published: Ann Intern Med. 1997;127(12):1128.
TO THE EDITOR:
We read with interest the review by Thomas and Roberts , which mainly discussed genetic defects in coagulation that cause hypercoagulability and thrombosis. We question the authors' summary statement: “No evidence indicates that the measurement of endogenous anticoagulant pathways has a useful role to play in assessing patients at risk for arterial thrombosis.” This generalization is probably relevant to arteriosclerotic thrombosis, but it does not apply to arterial thrombosis in patients suspected of having the antiphospholipid syndrome. As correctly stated by the authors themselves earlier in their review, “… persons with hypercoagulable states include patients with the antiphospholipid syndrome who can develop both arterial and venous thrombosis.”
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