M. Ammar Hatahet, MD
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Hatahet M.; Intractable Hiccups and Gastroesophageal Reflux Disease. Ann Intern Med. 1997;127:1135. doi: 10.7326/0003-4819-127-12-199712150-00036
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Published: Ann Intern Med. 1997;127(12):1135.
TO THE EDITOR:
I read with interest the brief communication by Brzana and Koch  describing 10 patients with intractable nausea who were found to have gastroesophageal reflux. One of my patients presented with intractable hiccups that did respond to traditional medical therapy. Results of physical examinations, laboratory evaluation, and abdominal radiography were all normal. Upper gastroendoscopy revealed severe reflux and esophagitis. The hiccups responded well to omeprazole. Schreiber and colleagues  described a similar case, in which gastroesophageal reflux caused intractable hiccups. An interesting fact is that hiccups in infants are strongly associated with reflux .
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