Dimitris A. Papanicolaou, MD; Ronald L. Wilder, MD, PhD; Stavros C. Manolagas, MD, PhD; George P. Chrousos, MD
Papanicolaou DA, Wilder RL, Manolagas SC, Chrousos GP. The Pathophysiologic Roles of Interleukin-6 in Human Disease. Ann Intern Med. 1998;128:127-137. doi: 10.7326/0003-4819-128-2-199801150-00009
Download citation file:
Published: Ann Intern Med. 1998;128(2):127-137.
Interleukin-6, an inflammatory cytokine, is characterized by pleiotropy and redundancy of action. Apart from its hematologic, immune, and hepatic effects, it has many endocrine and metabolic actions. Specifically, it is a potent stimulator of the hypothalamic-pituitary-adrenal axis and is under the tonic negative control of glucocorticoids. It acutely stimulates the secretion of growth hormone, inhibits thyroid-stimulating hormone secretion, and decreases serum lipid concentrations. Furthermore, it is secreted during stress and is positively controlled by catecholamines. Administration of interleukin-6 results in fever, anorexia, and fatigue. Elevated levels of circulating interleukin-6 have been seen in the steroid withdrawal syndrome and in the severe inflammatory, infectious, and traumatic states potentially associated with the inappropriate secretion of vasopressin. Levels of circulating interleukin-6 are also elevated in several inflammatory diseases, such as rheumatoid arthritis. Interleukin-6 is negatively controlled by estrogens and androgens, and it plays a central role in the pathogenesis of the osteoporosis seen in conditions characterized by increased bone resorption, such as sex-steroid deficiency and hyperparathyroidism. Overproduction of interleukin-6 may contribute to illness during aging and chronic stress. Finally, administration of recombinant human interleukin-6 may serve as a stimulation test for the integrity of the hypothalamic-pituitary-adrenal axis.
Learn more about subscription options.
Register Now for a free account.
Endocrine and Metabolism, Nephrology, Rheumatology, Thyroid Disorders, Fluid and Electrolyte Disorders.
Results provided by:
Copyright © 2016 American College of Physicians. All Rights Reserved.
Print ISSN: 0003-4819 | Online ISSN: 1539-3704
Conditions of Use
This PDF is available to Subscribers Only