Charles M. Grossman, MD
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Grossman CM. Total Cholesterol and Death from Coronary Heart Disease in Older Persons. Ann Intern Med. 1998;128:242. doi: 10.7326/0003-4819-128-3-199802010-00013
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Published: Ann Intern Med. 1998;128(3):242.
TO THE EDITOR:
There are several problems with Corti and colleagues' attempt to correlate death from coronary heart disease and cholesterol levels in older persons . First, calculations from crude mortality rates, requiring adjustments to achieve results that are the opposite of the raw data, can hardly be called observational evidence (as is done twice in the Discussion section). Second, statistical significance occurs only when the 44 deaths that occurred in the first year were excluded from the analysis. The authors collected these data in accordance with their own experimental design. The authors then argue that persons in the last year of life may have had several terminal illnesses. This argument applies to persons who died in the other 4 years of the study.
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