Mario Sarcletti, MD; Anton Petter, MD; Robert Zangerle, MD
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Sarcletti M., Petter A., Zangerle R.; Indinavir and Interstitial Nephritis. Ann Intern Med. 1998;128:320. doi: 10.7326/0003-4819-128-4-199802150-00021
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Published: Ann Intern Med. 1998;128(4):320.
TO THE EDITOR:
Kopp and colleagues  report that indinavir crystalluria is associated with a novel syndrome that consists primarily of back or flank pain with crystalluria but without nephrolithiasis. In four of the patients who had this syndrome, renal parenchymal defects were shown on computed tomography. The authors argue that it is unknown whether patients with this complication subsequently develop chronic deficits in renal function, because serum creatinine levels were only mildly and transiently elevated in two of the patients. However, therapy was discontinued permanently in two patients and continued at a lower dose in another. Only one male patient continued therapy without a change in dosage. Did this patient have renal dysfunction? Did he increase fluid intake?
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