John V.L. Sheffield, MD; Eric B. Larson, MD, MPH
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Sheffield J., Larson E.; Intensity of Anticoagulation To Prevent Stroke in Patients with Atrial Fibrillation. Ann Intern Med. 1998;128:408. doi: 10.7326/0003-4819-128-5-199803010-00013
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Published: Ann Intern Med. 1998;128(5):408.
We agree that INRs of 2.0 or greater seem to provide optimal protection against embolic stroke and that the case–control study by Hylek and colleagues  demonstrates some protection against embolic stroke in the INR range of 1.6 to 2.0 Although it may be reasonable to target an INR of 2.0 within a range of 1.6 to 2.5 for some patients, we believe that several points must be considered before a less effective level of anticoagulation is accepted for elderly patients, who are also at highest risk for embolic stroke.
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Print ISSN: 0003-4819 | Online ISSN: 1539-3704
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