Mario Luppi, MD; M. Grazia Ferrari, PhD; Giuseppe Torelli, MD
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Luppi M., Ferrari M., Torelli G.; Hepatitis C Virus Genotype Distribution in B-Cell Non-Hodgkin Lymphoma. Ann Intern Med. 1998;128:602. doi: 10.7326/0003-4819-128-7-199804010-00027
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Published: Ann Intern Med. 1998;128(7):602.
TO THE EDITOR:
Epidemiologic studies have shown hepatitis C virus (HCV) infection in a statistically significant proportion of de novo B-cell non-Hodgkin lymphomas that are not complicating the course of type II mixed cryoglobulinemia [1-3].
To study the influence of specific HCV genotypes on the pathogenesis of B-cell non-Hodgkin lymphoma, we analyzed 97 HCV-positive (anti-HCV antibody-positive and HCV RNA-positive) patients, including 35 patients with B-cell non-Hodgkin lymphoma that was not complicating the course of type II mixed cryoglobulinemia, 27 patients undergoing long-term hemodialysis, and 35 patients with chronic liver disease. The HCV genotype was determined by using a genotype-specific primer polymerase chain reaction method . Results are summarized in the (Table 1). The prevalence of hepatitis C virus genotype 1b/II was unexpectedly lower in patients with B-cell non-Hodgkin lymphoma (25.7%) than in patients undergoing long-term hemodialysis (66.7%; P = 0.0013) and those with chronic liver disease (62.8%; P = 0.001). Conversely, the prevalence of genotypes 2a/III and 2b/IV was higher in patients with B-cell non-Hodgkin lymphoma (42.8%) than in the hemodialysis group (14.8%; P = 0.01) and chronic liver disease group (14.2%; P = 0.008).
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