Gilles Boccara, MD; Claude Mann, MD; Gilles Guillon, MD
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Boccara G, Mann C, Guillon G. Secretion of Vasopressin from a Human Pheochromocytoma. Ann Intern Med. 1998;128:1049. doi: 10.7326/0003-4819-128-12_Part_1-199806150-00031
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Published: Ann Intern Med. 1998;128(12_Part_1):1049.
TO THE EDITOR:
A 12-year-old boy presented to the hospital with exertional dyspnea, resting tachycardia (heart rate, 180 beats/min), and hypertension (blood pressure, 220/110 mm Hg). Investigations showed a left para-aortic pheochromocytoma, and the patient was scheduled for surgical resection of the tumor.
Intraoperative manipulation of the tumor lead to hypertension; however, systolic blood pressure never exceeded 220 mm Hg, and heart rate never exceeded 100 beats/min because of treatment with a calcium-channel blocker and a β1-adrenergic blocker. Plasma concentrations of catecholamine did not vary markedly, but the plasma level of arginine vasopressin did: The level was 220 pmol/L (normal, 0.4 to 4.0 pmol/L) during surgical manipulation and 26 pmol/L immediately after tumor resection (Table 1). Postoperative cytologic analysis confirmed a well-differentiated pheochromocytoma.
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