Eddys Disla, MD; Louis D'Eamour, RN; Michael Cioriou, MD
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Disla E, D'Eamour L, Cioriou M. Hydroxyurea-Associated Leg Ulceration. Ann Intern Med. 1998;129:252. doi: 10.7326/0003-4819-129-3-199808010-00018
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Published: Ann Intern Med. 1998;129(3):252.
TO THE EDITOR:
In their recent report, Best and colleagues  provide us with a fresh look at the association between leg ulcers and hydroxyurea therapy. Their conclusion that cessation of hydroxyurea therapy is necessary to achieve healing is nevertheless questionable. Because hydroxyurea is used to treat serious underlying systemic disorders, this approach is often impractical, as illustrated by a patient we recently treated at our wound care center.
A 68-year-old man was referred with many painful, nonhealing ulcers that had been on his right leg for 1 year. The patient had a history of polycythemia vera, diagnosed in 1992, and had received hydroxyurea, 1.5 g/d, plus phlebotomy for 5 years. He also had hypertensive heart disease that was well controlled with extended-release nifedipine, 30 mg/d; metoprolol, 25 mg orally twice daily; furosemide, 20 mg; and aspirin, 325 mg/d. Physical examination revealed good peripheral pulses; slight leg edema; and five ulcers, ranging from 0.3 to 1 cm in diameter. His hemoglobin level was 16.9 g/dL. Results of routine chemistry and serology were unremarkable.
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Print ISSN: 0003-4819 | Online ISSN: 1539-3704
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