Mark E. McCaulley, MD
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McCaulley ME. Guidelines for the Clinical Diagnosis of Lyme Disease. Ann Intern Med. 1998;129:422-423. doi: 10.7326/0003-4819-129-5-199809010-00017
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Published: Ann Intern Med. 1998;129(5):422-423.
TO THE EDITOR:
The position paper on laboratory diagnosis of Lyme disease  is based on a widely accepted paradigm that is inconsistent with a growing body of medical literature. According to this paradigm, cases of Lyme disease are overwhelmingly seropositive and are unlikely to be associated with persistent symptoms after presumed adequate therapy. In addition, any patients remaining persistently symptomatic are presumed to no longer have Lyme disease at all but rather to have such conditions as fibromyalgia, depression, or the chronic fatigue syndrome and, as a result, to be unlikely to respond to additional antibiotic therapy . Such presumptions are inconsistent with an increasing number of reports.
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Print ISSN: 0003-4819 | Online ISSN: 1539-3704
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