John L. Doppman, MD; Lynnette Nieman, MD; Edward Oldfield, MD
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Doppman J., Nieman L., Oldfield E.; Jugular Vein Sampling in Cushing Disease. Ann Intern Med. 1998;129:424. doi: 10.7326/0003-4819-129-5-199809010-00021
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Published: Ann Intern Med. 1998;129(5):424.
As noted by Dr. Thaler, there is a discrepancy between the lower boundaries of the ranges of the central-to-peripheral ACTH ratios described in the Results section and the ranges of the data shown in the figure. The reason for this discrepancy is that the figure presents all the data, whereas the ranges presented in the Results section refer just to those cases with positive sampling results (that is, ratios >2 before and >3 after CRH administration). Previously in the text we had commented that 16 of 20 patients (80%) with surgically proven Cushing disease had positive findings on jugular vein sampling. Our intention in highlighting and contrasting the ranges for these positive results was to point out that the positive jugular vein samples were lower and more tightly clustered than the positive petrosal vein samples both before and after CRH administration; petrosal ratios ranged from 110.5 to 407.1 before and after CRH but jugular values ranged from only 3.7 to 14.9. We should also clarify that the average ratios of central to peripheral ACTH reported with these ranges in the text and in the abstract pertain just to these positive sampling results.
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Print ISSN: 0003-4819 | Online ISSN: 1539-3704
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