Shinji Teramoto, MD; Hiroshi Yamamoto, MD; Yasuyoshi Ouchi, MD
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Teramoto S., Yamamoto H., Ouchi Y.; Increased Synovial Interleukin-8 and Interleukin-6 Levels in Pseudogout Associated with Granulocyte Colony-Stimulating Factor. Ann Intern Med. 1998;129:424-425. doi: 10.7326/0003-4819-129-5-199809010-00023
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Published: Ann Intern Med. 1998;129(5):424-425.
TO THE EDITOR:
Although granulocyte colony-stimulating factor (GCSF) substantially shortens the period of severe neutropenia that follows high-dose chemotherapy, several side effects, including bone pain, were noted in patients given GCSF . Furthermore, Sandor and colleagues  recently suggested that pseudogout can be caused by GCSF. Because GCSF can provoke the other proinflammatory cytokines, GCSF-induced cytokines may affect pseudogout in joints. However, no evidence is available on the direct involvement of GCSF-related cytokines in pseudogout. We report a case of pseudogout after GCSF treatment in which synovial levels of GCSF, interleukin (IL)-8, and IL-6 were markedly increased.
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