Christopher M. Rembold, MD
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Rembold C.; Gemfibrozil To Prevent Myocardial Infarction. Ann Intern Med. 1998;129:750. doi: 10.7326/0003-4819-129-9-199811010-00026
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Published: Ann Intern Med. 1998;129(9):750.
TO THE EDITOR:
The West of Scotland Coronary Prevention Study  demonstrated that pravastatin prevented myocardial infarction and cardiovascular death in asymptomatic men with high low-density lipoprotein (LDL) cholesterol levels. Since publication of this and other trials, statins have become the primary antidyslipidemic agents prescribed in the United States despite the proven benefit of gemfibrozil and niacin. For example, the Helsinki Heart Study (HHS) showed that gemfibrozil prevented myocardial infarction in asymptomatic men at high risk for coronary artery disease .
I reanalyzed the West of Scotland study and HHS with the number needed to treat (NNT) concept. The latter measure is defined as the number of patients who need to be treated for a given duration to prevent one event . It is the reciprocal of the absolute risk reduction.
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Print ISSN: 0003-4819 | Online ISSN: 1539-3704
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