Philip M. Bulman; Gene Hunder, MD, MS
Bulman P., Hunder G.; New Approaches for Treatment of Systemic Lupus Erythematosus. Ann Intern Med. 1998;129:1095-1096. doi: 10.7326/0003-4819-129-12-199812150-00051
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Published: Ann Intern Med. 1998;129(12):1095-1096.
New approaches to treating systemic lupus erythematosus (SLE) are being developed as a result of advances in basic research related to the disease. Treatments include the use of genetically engineered molecules, immunosuppression, bone marrow transplantation, and immunoablative therapy.
Lupus is characterized by overactive B lymphocytes that circulate in the blood and most body tissues. Contact between autoreactive B and T cells, which is mediated by proteins on the surface of both cell types, is required for pathogenic autoantibody production. The new treatments focus on B and T lymphocytes and their interactions in an effort to prevent production of antinuclear antibodies.
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Rheumatology, Lupus Erythematosus.
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Print ISSN: 0003-4819 | Online ISSN: 1539-3704
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