Franc Strle, MD; Robert B. Nadelman, MD; Joze Cimperman, MD; John Nowakowski, MD; Roger N. Picken, PhD; Ira Schwartz, PhD; Vera Maraspin, MD; Maria E. Aguero-Rosenfeld, MD; Shobha Varde, MS; Stanka Lotric-Furlan, MD; Gary P. Wormser, MD
Strle F, Nadelman RB, Cimperman J, Nowakowski J, Picken RN, Schwartz I, et al. Comparison of Culture-Confirmed Erythema Migrans Caused by Borrelia burgdorferi sensu stricto in New York State and by Borrelia afzelii in Slovenia. Ann Intern Med. 1999;130:32-36. doi: 10.7326/0003-4819-130-1-199901050-00006
Download citation file:
Published: Ann Intern Med. 1999;130(1):32-36.
The clinical manifestations of Lyme borreliosis in North America and Europe seem to differ, but a systematic comparison has never been done.
To compare European and U.S. patients with culture-confirmed erythema migrans.
Prospective, clinical cohort study.
University medical centers in Westchester County, New York, and Ljubljana, Slovenia.
119 U.S. patients with Borrelia burgdorferi sensu stricto infection and 85 Slovenian patients with B. afzelii infection.
Interview, physical examination, and laboratory assays.
Compared with Slovenian patients, U.S. patients had erythema migrans for a briefer duration (median duration, 4 days compared with 14 days; P < 0.001) but were more likely to have systemic symptoms (P = 0.01), abnormal findings on physical examination (P < 0.001), and seroreactivity (P < 0.001). Central clearing of erythema migrans lesions was more likely in Slovenian patients (P < 0.001).
Erythema migrans caused by B. afzelii in Slovenia and erythema migrans caused by B. burgdorferi in New York have distinct clinical presentations. Caution should be used when clinical and laboratory experience from one side of the Atlantic is applied to patients on the other.
Learn more about subscription options.
Register Now for a free account.
Infectious Disease, Tick-Borne Diseases.
Results provided by:
Copyright © 2016 American College of Physicians. All Rights Reserved.
Print ISSN: 0003-4819 | Online ISSN: 1539-3704
Conditions of Use
This PDF is available to Subscribers Only