Richard E. Sampliner, MD
Sampliner R.; Adenocarcinoma of the Esophagus and Gastric Cardia: Is There Progress in the Face of Increasing Cancer Incidence?. Ann Intern Med. 1999;130:67-69. doi: 10.7326/0003-4819-130-1-199901050-00014
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Published: Ann Intern Med. 1999;130(1):67-69.
From the late 1970s to the mid-1980s, the incidence of adenocarcinoma of the esophagus and gastric cardia increased more rapidly than that of any other cancer in the United States (1). Adenocarcinoma of the esophagus has continued to increase in frequency in the early 1990s. An estimated 25 000 people die every year of these cancers in the United States, and a similar trend has been noted in western Europe (2).
Adenocarcinoma of the esophagus itself usually occurs in patients who have Barrett esophagus (3). Adenocarcinoma of the gastric cardia and esophagogastric junction is associated with Barrett esophagus about 40% of the time (4). Unfortunately, the terminology for defining adenocarcinoma of the proximal stomach is not standardized. The International Classification of Diseases for oncology lumps together cancers of the cardia and the gastroesophageal junction. For example, the origin of a tumor may be described as the gastric cardia “when the epicenter is at the gastroesophageal junction” (4) or the esophagogastric junction “when the vertical midpoint of the tumor was ≥ 2 cm above or below the esophagogastric junction” (5).
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Gastroenterology/Hepatology, Hematology/Oncology, Esophageal Disorders, Gastrointestinal Cancer.
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Print ISSN: 0003-4819 | Online ISSN: 1539-3704
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